How to Use Retaining Frame for Ultrasonic Nebulizer ? Ultrasonic wave nebulizers were invented in 1964 as a new more portable nebulizer. The technology inside an ultrasonic wave nebulizer is to have an electronic oscillator generate  a high frequency ultrasonic wave, which causes the mechanical vibration of a piezoelectric element. This vibrating element is in contact with a liquid reservoir and its high frequency vibration is sufficient to produce a vapor mist. As they create aerosols from ultrasonic vibration instead of using a heavy air compressor, they only have a weight around 170 grams (6.0 oz). Another advantage is that the ultrasonic vibration is almost silent.